Tissue regeneration Scaffolds is Commercially and Clinically viable. Biomaterials are used in the Fabrication of Scaffolds for Tissue science. The three individual groups of Biomaterials which is used in Scaffolds Fabrication are Natural Polymers, Ceramics and Synthetic polymers. Collagen Scaffolds are used in Bone Tissue engineering. Successful Tissue engineering scaffolds used in Bone, Skin, Bladder, etc. In the field of Regenerative medicine, the idea of Gene delivery vector along with the Tissue engineered Scaffold.